Total Zinc Intake May Modify the Glucose-Raising Effect of a Zinc Transporter (SLC30A8) Variant A 14-Cohort Meta-Analysis
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چکیده
of a Zinc Transporter (SLC30A8) Variant A 14-Cohort Meta-Analysis Stavroula Kanoni, Jennifer A. Nettleton, Marie-France Hivert, Zheng Ye, Frank J.A. van Rooij, Dmitry Shungin, Emily Sonestedt, Julius S. Ngwa, Mary K. Wojczynski, Rozenn N. Lemaitre, Stefan Gustafsson, Jennifer S. Anderson, Toshiko Tanaka, George Hindy, Georgia Saylor, Frida Renstrom, Amanda J. Bennett, Cornelia M. van Duijn, Jose C. Florez, Caroline S. Fox, Albert Hofman, Ron C. Hoogeveen, Denise K. Houston, Frank B. Hu, Paul F. Jacques, Ingegerd Johansson, Lars Lind, Yongmei Liu, Nicola McKeown, Jose Ordovas, James S. Pankow, Eric J.G. Sijbrands, Ann-Christine Syvänen, André G. Uitterlinden, Mary Yannakoulia, M. Carola Zillikens, Nick J. Wareham, Inga Prokopenko, Stefania Bandinelli, Nita G. Forouhi, L. Adrienne Cupples, Ruth J. Loos, Goran Hallmans, Josée Dupuis, Claudia Langenberg, Luigi Ferrucci, Stephen B. Kritchevsky, Mark I. McCarthy, Erik Ingelsson, Ingrid B. Borecki, Jacqueline C.M. Witteman, Marju Orho-Melander, David S. Siscovick, James B. Meigs, Paul W. Franks, and George V. Dedoussis, for the MAGIC Investigators*
منابع مشابه
Total Zinc Intake May Modify the Glucose-Raising Effect of a Zinc Transporter (SLC30A8) Variant
OBJECTIVE Many genetic variants have been associated with glucose homeostasis and type 2 diabetes in genome-wide association studies. Zinc is an essential micronutrient that is important for β-cell function and glucose homeostasis. We tested the hypothesis that zinc intake could influence the glucose-raising effect of specific variants. RESEARCH DESIGN AND METHODS We conducted a 14-cohort met...
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Zinc transporter 8 genetic variant SLC30A8 has been associated with postpartum risk of type 2 diabetes among women with gestational diabetes mellitus (GDM). Gestational weight gain is one of the strongest risk factors for postpartum hyperglycemia. We assessed the interaction between type 2 diabetes-associated SLC30A8 rs13266634 and gestational weight gain on 1-5 years of postpartum glycemic cha...
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OBJECTIVE The SLC30A8 gene encodes the islet-specific transporter ZnT-8, which is hypothesized to provide zinc for insulin-crystal formation. A polymorphic variant in SLC30A8 is associated with altered susceptibility to type 2 diabetes. Several groups have examined the effect of global Slc30a8 gene deletion but the results have been highly variable, perhaps due to the mixed 129SvEv/C57BL/6J gen...
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BACKGROUND Several studies have shown the association of solute carrier family 30 (zinc transporter) member 8 (SLC30A8) rs13266634 with type 2 diabetes (T2D). However, the association of alternative variants and haplotypes of SLC30A8 with T2D have not been studied in different populations. The aim of this study is to assess the association of the alternative SLC30A8 variants, rs7002176 and rs19...
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Advances in our understanding of the genetics of type 2 diabetes have been astronomical over the past decade with more than 100 single nucleotide polymorphisms (SNPs) associated with modest increases in diabetes risk and differences in related traits such as fasting glucose (1,2). However, these SNPs have contributed more to elucidating biologic pathways than predicting diabetes risk (3). Nonet...
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تاریخ انتشار 2011